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Regardless of the questionable performance of opioids in managing CNCP and their high prices of Uncomfortable side effects, the absence of available option prescription drugs as well as their clinical limits and slower onset of action has brought about an overreliance on opioids. Conolidine is undoubtedly an indole alkaloid derived from the bark of
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Conolidine’s analgesic effects stem from its conversation with non-opioid pain pathways. Unlike opioids, which bind to µ-opioid receptors during the central nervous technique, conolidine modulates alternate molecular targets. A Science Advances study found that conolidine interacts Using the atypical chemokine receptor ACKR3/CXCR7, which regulat